3D structural modeling
for clinicians

This is designed to explain how mutations will impact the behaviour of a cancer driving protein (the target) and its susceptibility to drugs. Our target audience is clinicians who wish to know how to use modeling approaches to select from clinically available drugs. Attendees will be shown how to visualize the patient’s protein structure using information already typically available in the clinic and taught how to evaluate the interactions made between the drug and the target. Using publicly available databases and freeware visualisation software, the attendees will also be shown how to create models of mutated targets and to assess the impact of these mutations on the interaction between the drug and its target. Examples of software solutions to model these changes, ranging from the simplistic to the complex will also be discussed.